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Review Article| Volume 26, ISSUE 1, P103-114, April 2010

Acute Laminitis: Medical and Supportive Therapy

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      References

        • Hood D.M.
        Laminitis in the horse.
        Vet Clin North Am Equine Pract. 1999; 15: 287-294
        • Pollitt C.C.
        Laminitis.
        in: Colahan P.T. Merritt A.M. Moore J.N. Equine medicine and surgery. 5th edition. Mosby, St Louis (MO)1999: 1521-1749
        • Nourian A.R.
        • Baldwin G.I.
        • van Eps A.W.
        • et al.
        Equine laminitis: ultrastructural lesions detected 24-30 hours after induction with oligofructose.
        Equine Vet J. 2007; 39: 360-364
      1. Croser EL, Pollitt CC. Acute laminitis: descriptive evaluation of serial hoof biopsies. In: Proceedings of the 52nd Annual Convention of the American Association of Equine Practitioners, San Antonio (TX); 2006. p. 542–5

        • Parsons C.S.
        • Orsini J.A.
        • Krafty R.
        • et al.
        Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997–2004).
        J Am Vet Med Assoc. 2007; 230: 885-889
        • Peloso J.G.
        • Cohen N.D.
        • Walker M.A.
        • et al.
        Case-control study of risk factors for the development of laminitis in the contralateral limb in Equidae with unilateral lameness.
        J Am Vet Med Assoc. 1996; 209: 1746-1749
        • Cohen N.D.
        • Parson E.M.
        • Seahorn T.L.
        • et al.
        Prevalence and factors associated with development of laminitis in horses with duodenitis/proximal jejunitis: 33 cases (1985–1991).
        J Am Vet Med Assoc. 1994; 204: 250-254
        • Cohen N.D.
        • Woods A.M.
        Characteristics and risk factors for failure of horses with acute diarrhea to survive: 122 cases (1990-1996).
        J Am Vet Med Assoc. 1999; 214: 382-390
        • Slater M.R.
        • Hood D.M.
        • Carter G.K.
        Descriptive epidemiological study of equine laminitis.
        Equine Vet J. 1995; 27: 364-367
        • Alford P.
        • Geller S.
        • Richrdson B.
        • et al.
        A multicenter, matched case-control study of risk factors for equine laminitis.
        Prev Vet Med. 2001; 49: 209-222
        • Bailey S.R.
        The pathogenesis of acute laminitis: fitting more pieces into the puzzle.
        Equine Vet J. 2004; 36: 199-203
        • Belknap J.K.
        • Giguere S.
        • Pettigrew A.
        • et al.
        Lamellar pro-inflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness: innate vs. adaptive immune response.
        Equine Vet J. 2007; 39: 42-47
        • Moore R.M.
        • Eades S.C.
        • Stokes A.M.
        Evidence for vascular and enzymatic events in the pathophysiology of acute laminitis: which pathway is responsible for initiation of this process in horses?.
        Equine Vet J. 2004; 36: 204-209
      2. Pollitt CC. Equine laminitis: a revised pathophysiology. In: Proceedings of the 45th Annual Convention of the American Association of Equine Practitioners. Albuquerque, NM; 1999. p. 188–92.

        • Hood D.M.
        The pathophysiology of developmental and acute laminitis.
        Vet Clin North Am Equine Pract. 1999; 15: 321-343
      3. Obel N. Studies of the histopathology of acute laminitis. In: Almgvist and Wilcsells Bottrykeri Ab Uppsala [thesis]; 1948.

        • Mogg K.C.
        • Pollitt C.C.
        Hoof and distal limb surface temperature in the normal pony under constant and changing ambient temperatures.
        Equine Vet J. 1992; 24: 134-139
        • Cripps P.J.
        • Eustace R.A.
        Radiological measurements from the feet of normal horses with relevance to laminitis.
        Equine Vet J. 1999; 31: 427-432
      4. Linford RL. A radiographic, morphometric, histological and ultrastructural investigation of lamellar function, abnormality and the associated radiographic findings for sound and foot sore thoroughbreds and horses with experimentally induced traumatic and alimentary laminitis [PhD thesis]. University of California, Davis, USA; 1987.

        • Miller M.A.
        • Pardo I.D.
        • Jackson L.P.
        • et al.
        Correlation of pituitary histomorphometry with adrenocorticotrophic hormone response to domperidone administration in the diagnosis of equine pituitary pars intermedia dysfunction.
        Vet Pathol. 2008; 45: 26-38
        • van Eps A.W.
        • Pollitt C.C.
        Equine laminitis induced with oligofructose.
        Equine Vet J. 2006; 38: 203-208
        • Parks A.
        Treatment of acute laminitis.
        Equine Vet Educ. 2003; 15: 273-280
        • Parks A.H.
        • Balch O.K.
        • Collier M.A.
        Treatment of acute laminitis. Supportive therapy.
        Vet Clin North Am Equine Pract. 1999; 15: 363-374
        • Van Eps A.W.
        • Pollitt C.C.
        Equine laminitis model: Lamellar histopathology seven days after induction with oligofructose.
        Equine Vet J. 2009; 41: 735-740
        • Wattle O.
        • Ekfalck A.
        • Funkquist B.
        • et al.
        Behavioural studies in healthy ponies subjected to short-term forced recumbency aiming at an adjunctive treatment in an acute attack of laminitis.
        Zentralbl Veterinarmed A. 1995; 42: 62-68
        • Fontaine G.L.
        • Belknap J.K.
        • Allen D.
        • et al.
        Expression of interleukin-1beta in the digital laminae of horses in the prodromal stage of experimentally induced laminitis.
        Am J Vet Res. 2001; 62: 714-720
        • Pollitt C.C.
        Basement membrane pathology: a feature of acute equine laminitis.
        Equine Vet J. 1996; 28: 38-46
      5. Abrahamsen EJ. How to manage acute pain in laminitis. In: Proceedings of the Congress of the British Equine Veterinary Association. Birmingham; 2005. p. 195–96.

        • Harding L.M.
        • Kristensen J.D.
        • Baranowski A.P.
        Differential effects of neuropathic analgesics on wind-up-like pain and somatosensory function in healthy volunteers.
        Clin J Pain. 2005; 21: 127-132
        • Arendt-Nielsen L.
        • Frokjaer J.B.
        • Staahl C.
        • et al.
        Effects of gabapentin on experimental somatic pain and temporal summation.
        Reg Anesth Pain Med. 2007; 32: 382-388
        • Jones E.
        • Vinuela-Fernandez I.
        • Eager R.A.
        • et al.
        Neuropathic changes in equine laminitis pain.
        Pain. 2007; 132: 321-331
      6. Terry RL, McDonnell SM, van Eps AW, et al. Pharmacokinetic profile and behavioral effects of gabapentin in the horse. J Vet Pharmacol Ther, in press.

        • Treiber K.
        • Carter R.
        • Gay L.
        • et al.
        Inflammatory and redox status of ponies with a history of pasture-associated laminitis.
        Vet Immunol Immunopathol. 2009; 129: 216-220
        • Faleiros R.R.
        • Nuovo G.J.
        • Belknap J.K.
        Calprotectin in myeloid and epithelial cells of laminae from horses with black walnut extract-induced laminitis. American College of Veterinary Internal Medicine.
        J Vet Intern Med. 2009; 23: 174-181
        • Faleiros R.R.
        • Leise B.B.
        • Westerman T.
        • et al.
        In vivo and in vitro evidence of the involvement of CXCL1, a keratinocyte-derived chemokine, in equine laminitis. American College of Veterinary Internal Medicine.
        J Vet Intern Med. 2009; 23: 1086-1096
        • Black S.J.
        Extracellular matrix, leukocyte migration and laminitis.
        Vet Immunol Immunopathol. 2009; 129: 161-163
        • Blikslager A.T.
        • Yin C.
        • Cochran A.M.
        • et al.
        Cyclooxygenase expression in the early stages of equine laminitis: a cytologic study.
        J Vet Intern Med. 2006; 20: 1191-1196
        • Black S.J.
        • Lunn D.P.
        • Yin C.
        • et al.
        Leukocyte emigration in the early stages of laminitis.
        Vet Immunol Immunopathol. 2006; 109: 161-166
        • Harkins J.D.
        • Carney J.M.
        • Tobin T.
        Clinical use and characteristics of the corticosteroids.
        Vet Clin North Am Equine Pract. 1993; 9: 543-562
        • Bailey S.R.
        • Elliott J.
        The corticosteroid laminitis story: 2. Science of if, when and how.
        Equine Vet J. 2007; 39: 7-11
        • Sykes B.W.
        • Furr M.O.
        Equine endotoxaemia–a state-of-the-art review of therapy.
        Aust Vet J. 2005; 83: 45-50
        • Coyne M.J.
        • Cousin H.
        • Loftus J.P.
        • et al.
        Cloning and expression of ADAM-related metalloproteases in equine laminitis.
        Vet Immunol Immunopathol. 2009; 129: 231-241
        • Kyaw-Tanner M.T.
        • Wattle O.
        • van Eps A.W.
        • et al.
        Equine laminitis: membrane type matrix metalloproteinase-1 (MMP-14) is involved in acute phase onset.
        Equine Vet J. 2008; 40: 482-487
        • Kyaw-Tanner M.
        • Pollitt C.C.
        Equine laminitis: increased transcription of matrix metalloproteinase-2 (MMP-2) occurs during the developmental phase.
        Equine Vet J. 2004; 36: 221-225
        • Nourian A.R.
        • Mills P.C.
        • Pollitt C.C.
        Development of intraosseous infusion of the distal phalanx to access the foot lamellar circulation in the standing, conscious horse.
        Vet J. 2009; ([Epub ahead of print])
      7. Fugler LA, Eades SC, Koch CE, et al. Clinical and matrix metalloproteinase inhibitory effects of pentoxifylline on carbohydrate overload laminitis: preliminary results. In: Proceedings of the 2nd AAEP Foundation Equine Laminitis Research Workshop. West Palm Beach; 2009. p. 44.

        • Bailey S.R.
        • Adair H.S.
        • Reinemeyer C.R.
        • et al.
        Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis.
        Vet Immunol Immunopathol. 2009; 129: 167-173
        • Weiss D.J.
        • Evanson O.A.
        Detection of activated platelets and platelet-leukocyte aggregates in horses.
        Am J Vet Res. 1997; 58: 823-827
        • Weiss D.J.
        • Evanson O.A.
        • McClenahan D.
        • et al.
        Evaluation of platelet activation and platelet-neutrophil aggregates in ponies with alimentary laminitis.
        Am J Vet Res. 1997; 58: 1376-1380
        • de la Rebiere de Pouyade G.
        • Grulke S.
        • Detilleux J.
        • et al.
        Evaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery.
        J Vet Emerg Crit Care (San Antonio). 2009; 19: 113-119
        • Pratt S.E.
        • Geor R.J.
        • McCutcheon L.J.
        Effects of dietary energy source and physical conditioning on insulin sensitivity and glucose tolerance in standard bred horses.
        Equine Vet J. 2006; : 579-584
        • Durham A.E.
        • Rendle D.I.
        • Newton J.E.
        The effect of metformin on measurements of insulin sensitivity and beta cell response in 18 horses and ponies with insulin resistance.
        Equine Vet J. 2008; 40: 493-500
        • van Eps A.W.
        • Pollitt C.C.
        Equine laminitis model: cryotherapy reduces the severity of lesions evaluated seven days after induction with oligofructose.
        Equine Vet J. 2009; 41: 741-746
        • van Eps A.W.
        • Pollitt C.C.
        Equine laminitis: cryotherapy reduces the severity of the acute lesion.
        Equine Vet J. 2004; 36: 255-260
        • Geor R.J.
        • Harris P.
        Dietary management of obesity and insulin resistance: countering risk for laminitis.
        Vet Clin North Am Equine Pract. 2009; 25 (vi): 51-65
        • Murray M.J.
        • Eichorn E.S.
        Effects of intermittent feed deprivation, intermittent feed deprivation with ranitidine administration, and stall confinement with ad libitum access to hay on gastric ulceration in horses.
        Am J Vet Res. 1996; 57: 1599-1603
        • Murray M.J.
        • Haven M.L.
        • Eichorn E.S.
        • et al.
        Effects of omeprazole on healing of naturally-occurring gastric ulcers in thoroughbred racehorses.
        Equine Vet J. 1997; 29: 425-429
        • Hood D.M.
        The mechanisms and consequences of structural failure of the foot.
        Vet Clin North Am Equine Pract. 1999; 15: 437-461