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- Acute laminitis.Vet Clin North Am Equine Pract. 1994; 10: 627-642
- Complications of unilateral weight bearing.Vet Clin North Am Equine Pract. 2008; 24 (621-642, ix)
- Overview of current laminitis research.Vet Clin North Am Equine Pract. 2010; 26: 51-63
- Are there shared mechanisms in the pathophysiology of different clinical forms of laminitis and what are the implications for prevention and treatment?.Vet Clin North Am Equine Pract. 2019; 35: 379-398
- Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.Chest. 1992; 101: 1644-1655
- A comparative review of equine SIRS, sepsis, and neutrophils.Front Vet Sci. 2019; 6: 69
- Sepsis-from human organ failure to laminar failure.Vet Immunol Immunopathol. 2009; 129: 155-157
- Scoring system for multiple organ dysfunction in adult horses with acute surgical gastrointestinal disease.J Vet Intern Med. 2016; 30: 1276-1283
- Prognostic value and development of a scoring system in horses with systemic inflammatory response syndrome.J Vet Intern Med. 2017; 31: 582-592
- Equine laminitis of alimentary origin: an experimental model.Am J Vet Res. 1975; 36: 441-444
- Evaluation of equine digital Starling forces and hemodynamics during early laminitis.Am J Vet Res. 1990; 51: 1930-1934
- Changes in the caecal flora associated with the onset of laminitis.Equine Vet J. 1978; 10: 249-252
- Ultrastructural study of the equine cecum during onset of laminitis.Am J Vet Res. 1986; 47: 1804-1812
- Intracecal endotoxin and lactate during the onset of equine laminitis: a preliminary report.Am J Vet Res. 1979; 40: 722-723
- Pathophysiology of acute laminitis.Vet Clin North Am Equine Pract. 1989; 5: 67-72
- Effects of low-dose oligofructose treatment administered via nasogastric intubation on induction of laminitis and associated alterations in glucose and insulin dynamics in horses.Am J Vet Res. 2009; 70: 624-632
- Equine laminitis induced with oligofructose.Equine Vet J. 2006; 38: 203-208
- Changes in equine hindgut bacterial populations during oligofructose-induced laminitis.Environ Microbiol. 2006; 8: 885-898
- Black walnut toxicosis in ten horses.J Am Vet Med Assoc. 1989; 195: 343-344
- Lamellar pro-inflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness: innate vs. adaptive immune response.Equine Vet J. 2007; 39: 42-47
- Basement membrane pathology: a feature of acute equine laminitis.Equine Vet J. 1996; 28: 38-46
- Laminar inflammatory gene expression in the carbohydrate overload model of equine laminitis.Equine Vet J. 2011; 43: 54-61
- Effects of a "two-hit" model of organ damage on the systemic inflammatory response and development of laminitis in horses.Vet Immunol Immunopathol. 2012; 150: 90-100
- Laminar chemokine mRNA concentrations in horses with carbohydrate overload-induced laminitis.Vet Immunol Immunopathol. 2011; 144: 45-51
- In vivo and in vitro evidence of the involvement of CXCL1, a keratinocyte-derived chemokine, in equine laminitis.J Vet Intern Med. 2009; 23: 1086-1096
- Laminar leukocyte accumulation in horses with carbohydrate overload-induced laminitis.J Vet Intern Med. 2011; 25: 107-115
- Calprotectin in myeloid and epithelial cells of laminae from horses with black walnut extract-induced laminitis.J Vet Intern Med. 2009; 23: 174-181
- Use of laser capture microdissection for the assessment of equine lamellar basal epithelial cell signalling in the early stages of laminitis.Equine Vet J. 2015; 47: 478-488
- Role of toll-like receptors in pathogen recognition.Clin Microbiol Rev. 2003; 16: 637-646
- Cloning and characterization of two toll/interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans.Blood. 1998; 91: 4020-4027
- Signal transduction by the lipopolysaccharide receptor, toll-like receptor-4.Immunology. 2004; 113: 153-162
- Stats: transcriptional control and biological impact.Nat Rev Mol Cell Biol. 2002; 3: 651-662
- Stat recruitment by tyrosine-phosphorylated cytokine receptors: an ordered reversible affinity-driven process.Immunity. 1995; 2: 677-687
- Structure, function, and regulation of STAT proteins.Mol Biosyst. 2006; 2: 536-550
- Tracking STAT nuclear traffic.Nat Rev Immunol. 2006; 6: 602-612
- Human serum from patients with septic shock activates transcription factors STAT1, IRF1, and NF-kappaB and induces apoptosis in human cardiac myocytes.J Biol Chem. 2005; 280: 42619-42626
- STAT proteins in innate immunity during sepsis: lessons from gene knockout mice.Acta Med Okayama. 2007; 61: 239-245
- Jaks, STATs, cytokines, and sepsis.Clin Diagn Lab Immunol. 2002; 9: 1153-1159
- Laminar regulation of STAT1 and STAT3 in black walnut extract and carbohydrate overload induced models of laminitis.J Vet Intern Med. 2012; 26: 996-1004
- Influence of digital hypothermia on lamellar events related to IL-6/gp130 signalling in equine sepsis-related laminitis.Equine Vet J. 2020; 52: 441-448
- Risk factors for development of acute laminitis in horses during hospitalization: 73 cases (1997-2004).J Am Vet Med Assoc. 2007; 230: 885-889
- Sepsis biomarkers: a review.Crit Care. 2010; 14: R15
- Concentrations of serum amyloid A and plasma fibrinogen in horses undergoing emergency abdominal surgery.J Vet Emerg Crit Care (San Antonio). 2016; 26: 344-351
- Biomarkers for sepsis.Biomed Res Int. 2014; 2014: 547818
- Application of acute phase protein measurements in veterinary clinical chemistry.Vet Res. 2004; 35: 163-187
- Plasma procalcitonin concentration in healthy horses and horses affected by systemic inflammatory response syndrome.J Vet Intern Med. 2015; 29: 1689-1691
- Kinetics of plasma procalcitonin, soluble CD14, CCL2 and IL-10 after a sublethal infusion of lipopolysaccharide in horses.Vet Immunol Immunopathol. 2017; 184: 29-35
- Effect of large colon ischemia and reperfusion on concentrations of calprotectin and other clinicopathologic variables in jugular and colonic venous blood in horses.Am J Vet Res. 2013; 74: 1281-1290
- Detection of calprotectin and apoptotic activity within the equine colon from horses with black walnut extract-induced laminitis.Vet Immunol Immunopathol. 2011; 144: 366-373
- Therapeutic hypothermia (cryotherapy) to prevent and treat acute laminitis.Vet Clin North Am Equine Pract. 2010; 26: 125-133
- Equine laminitis: cryotherapy reduces the severity of the acute lesion.Equine Vet J. 2004; 36: 255-260
- Equine laminitis model: cryotherapy reduces the severity of lesions evaluated seven days after induction with oligofructose.Equine Vet J. 2009; 41: 741-746
- Digital hypothermia inhibits early lamellar inflammatory signalling in the oligofructose laminitis model.Equine Vet J. 2012; 44: 230-237
- Effect of continuous digital hypothermia on lamellar inflammatory signaling when applied at a clinically-relevant timepoint in the oligofructose laminitis model.J Vet Intern Med. 2018; 32: 450-458
- Prophylactic digital cryotherapy is associated with decreased incidence of laminitis in horses diagnosed with colitis.Equine Vet J. 2014; 46: 554-559
- Cyclooxygenase expression in the early stages of equine laminitis: a cytologic study.J Vet Intern Med. 2006; 20: 1191-1196
- Descriptive epidemiological study of equine laminitis.Equine Vet J. 1995; 27: 364-367
- Histopatologia das lâminas do casco de equinos com laminite aguda induzida e tratados com ketoprofeno, fenilbutazona e flunixin meglumine.Arq Bras Med Vet Zootec. 2010; 62: 241-250
Belknap JK. Pharmacology: Is there a scientific basis for anti-inflammatory therapy in laminitis. Paper presented at: 5th International Conference of Laminitis and Disease of the Foot 2008; Palm Beach, FL.
- Endotoxin-neutralizing activity of polymyxin B in blood after IV administration in horses.Am J Vet Res. 2006; 67: 642-647
- Anti-inflammatory effects of four potential anti-endotoxaemic drugs assessed in vitro using equine whole blood assays.J Vet Pharmacol Ther. 2015; 38: 290-296
- Polymyxin B protects horses against induced endotoxaemia in vivo.Equine Vet J. 2004; 36: 397-401
- Pentoxifylline reduces acute lung injury in chronic endotoxemia.J Surg Res. 2003; 115: 92-99
- Pentoxifylline inhibits mediator synthesis in an equine in vitro whole blood model of endotoxemia.Circ Shock. 1994; 44: 216-220
- Evaluation of lipopolysaccharide-induced activation of equine neutrophils.Am J Vet Res. 2002; 63: 811-815
- Effects of pentoxifylline infusion on response of horses to in vivo challenge exposure with endotoxin.Am J Vet Res. 1997; 58: 1300-1307
- Effect of pentoxifylline, flunixin meglumine, and their combination on a model of endotoxemia in horses.Am J Vet Res. 1997; 58: 1291-1299
- Plasma matrix metalloproteinase activity in horses after intravenous infusion of lipopolysaccharide and treatment with matrix metalloproteinase inhibitors.Am J Vet Res. 2013; 74: 473-480
- Clinical and matrix metalloproteinase inhibitory effects of pentoxifyllin on carbohydrate overload laminitis: preliminary results.J Equine Vet Sci. 2010; 30: 106-107
- Pharmacokinetics of pentoxifylline and its 5-hydroxyhexyl metabolite after oral and intravenous administration of pentoxifylline to healthy adult horses.Am J Vet Res. 2006; 67: 1621-1627
- Evaluation of dimethyl sulphoxide effects on initial response to endotoxin in the horse.Equine Vet J. 2008; 40: 358-363
- Role of oxidative tissue injury in the pathophysiology of experimentally induced equine laminitis: a comparison of 2 models.J Vet Intern Med. 2011; 25: 540-548
- Inflammation and coagulation.Crit Care Med. 2010; 38: S26-S34
- Assessment of platelet biology in equine patients with systemic inflammatory response syndrome.J Vet Diagn Invest. 2020; (1040638720983791)
- Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis.Vet Immunol Immunopathol. 2009; 129: 167-173
- Effect of a competitive inhibitor of platelet aggregation on experimentally induced laminitis in ponies.Am J Vet Res. 1998; 59: 814-817
- Effects of clopidogrel and aspirin on platelet aggregation, thromboxane production, and serotonin secretion in horses.J Vet Intern Med. 2011; 25: 116-122
- Evaluation of low-molecular-weight heparin for the prevention of equine laminitis after colic surgery.J Vet Emerg Crit Care (San Antonio). 2009; 19: 113-119
- The effect of lidocaine on in vitro adhesion and migration of equine neutrophils.Vet Immunol Immunopathol. 2009; 129: 137-142
- Effect of intravenous lidocaine administration on laminar inflammation in the black walnut extract model of laminitis.Equine Vet J. 2010; 42: 261-269
- The dose-related effects of ketamine on mortality and cytokine responses to endotoxin-induced shock in rats.Anesth Analg. 2003; 97: 1769-1772
- Ketamine inhibits LPS-induced tumour necrosis factor-alpha and interleukin-6 in an equine macrophage cell line.Vet Res. 2005; 36: 257-262
- Clinical and immunomodulating effects of ketamine in horses with experimental endotoxemia.J Vet Intern Med. 2011; 25: 934-943
- Effect of leukapheresis on the leukogram of horses subjected to a "sepsis-related" SIRS model based on oligofructose gastric administration.Equine Vet Edu. 2017; 29: 13
- Clinical effects of leukapheresis in horses subjected to a “sepsis-related” SIRS model based on oligofructose gastric adminstration..Equine Vet Edu. 2017; 29: 12-13
- Inhibition of Janus kinase 2 and signal transduction and activator of transcription 3 protect against cecal ligation and puncture-induced multiple organ damage and mortality.J Trauma. 2009; 66: 859-865
- Intrahepatic STAT-3 activation and acute phase gene expression predict outcome after CLP sepsis in the rat.Am J Phys. 1998; 275: G1423-G1429
- Signal transducer and activator of transcription 3 signaling within hepatocytes attenuates systemic inflammatory response and lethality in septic mice.Hepatology. 2007; 46: 1564-1573