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Review Article| Volume 39, ISSUE 1, P115-131, April 2023

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Streptococcus equi Subspecies equi

Published:February 01, 2023DOI:https://doi.org/10.1016/j.cveq.2022.11.006

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      References

        • Boyle A.G.
        • Timoney J.F.
        • Newton J.R.
        • et al.
        Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles-revised consensus statement.
        J Vet Intern Med. 2018; 32: 633-647
        • George J.L.
        • Reif J.S.
        • Shiedeler R.K.
        • et al.
        Identification of carriers of Streptococcus equi in a naturally infected herd.
        J Am Vet Med Assoc. 1983; 183: 8-84
        • Sweeney C.R.
        • Benson C.E.
        • Whitlock R.H.
        • et al.
        Description of an epizootic and persistence of Streptococcus equi infections in horses.
        J Am Vet Med Assoc. 1989; 194: 1281-1285
        • Duffee L.R.
        • Stefanovski D.
        • Boston R.C.
        • et al.
        Predictor variables for and complications associated with Streptococcus equi subsp equi infection in horses.
        J Am Vet Med Assoc. 2015; 247: 1161-1168
        • Waller A.S.
        New perspectives for the diagnosis, control, treatment, and prevention of strangles in horses.
        Vet Clin North Am Equine Pract. 2014; 30: 591-607
        • Tscheschlok L.
        • Venner M.
        • Steward K.
        • et al.
        Decreased clinical severity of strangles in weanlings associated with restricted seroconversion to optimized streptococcus equi ssp equi assays.
        J Vet Intern Med. 2018; 32: 459-464
        • Morris E.R.A.
        • Boyle A.G.
        • Riihimäki M.
        • et al.
        Differences in the genome, methylome, and transcriptome do not differentiate isolates of Streptococcus equi subsp. equi from horses with acute clinical signs from isolates of inapparent carriers.
        PLoS One. 2021; 16: e0252804
        • Pringle J.
        • Venner M.
        • Tscheschlok L.
        • et al.
        Markers of long term silent carriers of Streptococcus equi ssp. equi in horses.
        J Vet Intern Med. 2020; 34: 2751-2757
        • Sweeney C.R.
        • Whitlock R.H.
        • Meirs D.A.
        • et al.
        Complications associated with Streptococcus equi infection on a horse farm.
        J Am Vet Med Assoc. 1987; 191: 1446-1448
        • Finno C.
        • Pusterla N.
        • Aleman M.
        • et al.
        Streptococcus equi meningoencephalomyelitis in a foal.
        J Am Vet Med Assoc. 2006; 229: 721-724
        • Pusterla N.
        • Whitcomb M.B.
        • Wilson W.D.
        Internal abdominal abscesses caused by Streptococcus equi subspecies equi in 10 horses in California between 1989 and 2004.
        Vet Rec. 2007; 160: 589
        • Mair T.S.
        • Sherlock C.E.
        Surgical drainage and post operative lavage of large abdominal abscesses in six mature horses.
        Equine Vet J Suppl. 2011; 39: 123
        • Pusterla N.
        • Watson J.L.
        • Affolter V.K.
        • et al.
        Purpura haemorrhagica in 53 horses.
        Vet Rec. 2003; 153: 118-121
        • Galán J.E.
        • Timoney J.F.
        Immune complexes in purpura hemorrhagica of the horse contain IgA and M antigen of Streptococcus equi.
        J Immunol. 1985; 135: 3134-3137
        • Kaese H.J.
        • Valberg S.J.
        • Hayden D.W.
        • et al.
        Infarctive purpura hemorrhagica in five horses.
        J Am Vet Med Assoc. 2005; 226: 1893-1898
        • Sponseller B.T.
        • Valberg S.J.
        • Tennent-Brown B.
        • et al.
        Severe acute rhabdomyolysis in 4 horses associated with Streptococcus equi subspecies equi infection.
        J Am Vet Med Assoc. 2005; 227: 1800-1807
        • Hunyadi L.
        • Sundman E.A.
        • Kass P.H.
        • et al.
        Clinical Implications and Hospital Outcome of Immune-Mediated Myositis in Horses.
        J Vet Intern Med. 2017; 31: 170-175
        • Finno C.J.
        • Gianino G.
        • Perumbakkam S.
        • et al.
        A missense mutation in MYH1 is associated with susceptibility to immune-mediated myositis in Quarter Horses.
        Skelet Muscle. 2018; 8: 7
        • Timoney J.F.
        • Kumar P.
        Early pathogenesis of equine Streptococcus equi infection(strangles) Equine.
        Vet J. 2008; 40: 637-642
        • Mukhtar M.M.
        • Timoney J.F.
        Chemotactic response of equine polymorphonuclear leucocytes to Streptococcus equi.
        Res Vet Sci. 1988; 45: 225-229
        • Timoney J.F.
        • Suther P.
        • Velineni S.
        • Artiushin C.
        The antiphagocytic activity of SeM OF Streptococcus equi requires capsule.
        J Equine Sci. 2014; 25: 53-56
        • Chanter N.
        • Newton J.R.
        • Wood J.L.N.
        • et al.
        Detection of strangles carriers.
        Vet Rec. 1998; 142: 496
        • Newton J.R.
        • Wood J.L.N.
        • Dunn K.A.
        • et al.
        Naturally occurring persistent and asymptomatic infection of the guttural pouches of horses with Streptococcus equi.
        Vet Rec. 1997; 140: 84-90
        • Newton J.R.
        • Wood J.L.N.
        • Chanter N.
        Strangles: long term carriage of Streptococcus equi in horses.
        Equine Vet Ed. 1997; 9: 98-102
        • Todd T.G.
        Strangles J Comp Path Therap. 1910; 23: 212-229
        • Hamlen H.J.
        • Timoney J.F.
        • Bell R.J.
        Epidemiologic and immunologic characteristics of Streptococcus equi infection in foals.
        J Am Vet Med Assoc. 1994; 204: 768-775
        • Timoney J.F.
        • Qin A.
        • Muthupalani S.
        • et al.
        Vaccine potential of novel surface exposed and secreted proteins of Streptococcus equi.
        Vaccine. 2007; 25: 5583-5590
        • Pringle J.
        • Storm E.
        • Waller A.
        • et al.
        Influence of penicillin treatment of horses with strangles on seropositivity to Streptococcus equi ssp. equi-specific antibodies.
        J Vet Intern Med. 2020; 34: 294-299
        • Galan J.E.
        • Timoney J.F.
        • Lengemann F.W.
        Passive transfer of mucosal antibody to Streptococcus equi in the foal.
        Infect Immun. 1986; 54: 202-206
        • Lindahl S.
        • Baverud V.
        • Egenvall A.
        • et al.
        Comparison of Sampling Sites and Laboratory Diagnostic Tests for S equi subsp. equi in Horses from Confirmed Strangles Outbreaks.
        J Vet Intern Med. 2013; 27: 542-547
        • Jerele S.
        • Davis E.
        • Mapes S.
        • et al.
        Survey of Serum Amyloid A and Bacterial and Viral Frequency Using qPCR Levels in Recently Captured Feral Donkeys from Death Valley National Park (California).
        Animals. 2020; 10: 1086
        • Boyle A.G.
        • Boston R.C.
        • O'Shea K.
        • et al.
        Optimization of an in vitro assay to detect Streptococcus equi subsp. equi.
        Vet Microbiol. 2012; 159: 406
        • Boyle A.G.
        • Rankin S.C.
        • Duffee L.
        • et al.
        S equi detection PCR assay for equine nasopharyngeal and guttural pouch wash samples.
        J Vet Intern Med. 2016; 30: 276-281
        • Boyle A.G.
        • Stefanovski D.
        • Rankin S.C.
        Determining optimal sampling site for Streptococcus equi subsp equi carriers using loop-mediated isothermal amplification.
        BMC Vet Res. 2017; 13: 75
        • Pringle J.
        • Venner M.
        • Tscheschlok L.
        • et al.
        Long term silent carriers of Streptococcus equi ssp. equi following strangles; carrier detection related to sampling site of collection and culture versus qPCR.
        Vet J. 2019; 246: 66-70
        • Pringle J.
        • Aspán A.
        • Riihimäki M.
        Repeated nasopharyngeal lavage predicts freedom from silent carriage of Streptococcus equi after a strangles outbreak.
        J Vet Intern Med. 2022; 36: 787-791
        • Morris E.R.A.
        • Hillhouse A.E.
        • Konganti K.
        • et al.
        Comparison of whole genome sequences of Streptococcus equi subsp. equi from an outbreak in Texas with isolates from within the region, Kentucky, USA, and other countries.
        Vet Microbiol. 2020; 243: 108638
        • Boyle A.G.
        • Sweeney C.R.
        • Kristula M.
        • et al.
        Factors associated with likelihood of horses having a high serum Streptococcus equi SeM-specific antibody titer.
        J Am Vet Med Assoc. 2009; 235: 973
        • Boyle A.G.
        • Smith M.A.
        • Boston R.C.
        • et al.
        SeM titers after natural outbreaks of Streptococcus equi equi in horses: a case-control study.
        J Am Vet Med Assoc. 2017; 250: 1432-1439
        • Delph K.M.
        • Beard L.A.
        • Trimble A.C.
        • et al.
        Strangles, convalescent Streptococcus equi subspecies equi M antibody titers, and presence of complications.
        J Vet Intern Med. 2019; 33: 275-279
        • Robinson C.
        • Steward K.F.
        • Potts N.
        • et al.
        Combining two serological assays optimises sensitivity and specificity for the identification of Streptococcus equi subsp. equi exposure.
        Vet J. 2013; 197: 188-191
        • Knowles E.J.
        • Mair T.S.
        • Butcher N.
        • et al.
        Use of a novel serological test for exposure to Streptococcus equi subspecies equi in hospitalised horses.
        Vet Rec. 2010; 166: 294
        • Boyle A.G.
        • Mitchell C.
        • Stefanovski D.
        • et al.
        Horses vaccinated with live attenuated intranasal strangles vaccine seroconvert to SEQ2190 and SeM.
        Equine Vet J. 2022; 54: 299-305
        • El-Hage C.M.
        • Bannai H.
        • Wiethoelter A.K.
        • et al.
        Serological responses of Australian horses using a commercial duplex indirect ELISA following vaccination against strangles.
        Aust Vet J. 2019; 97: 220-224
        • Durham A.E.
        • Kemp-Symonds J.
        Failure of serological testing for antigens A and C of Streptococcus equi subspecies equi to identify guttural pouch carriers.
        Equine Vet J. 2021; 53: 38-43
        • Davidson A.
        • Traub-Dargatz J.L.
        • Magnuson R.
        • et al.
        Lack of correlation between antibody titers to fibrinogen-binding protein of Streptococcus equi and persistent carriers of strangles.
        J Vet Diagn Invest. 2008; 20: 457
        • Newton J.R.
        • Verheyen K.
        • Talbot N.C.
        • et al.
        Control of strangles outbreaks by isolation of guttural pouch carriers identified using PCR and culture of Streptococcus equi.
        Equine Vet J. 2000; 32: 515
        • Boyle A.G.
        Strangles and its complications.
        Eq Vet Educ. 2017; 29: 149-157
        • Boyle A.G.
        Streptococcus equi subsp. equi infection (Strangles).
        in: Smith N.P. Van Metre D.C. Pusterla N. Large animal internal medicine. 6th edition. Elsevier, St. Louis2020: 559-564
        • Ramey D.
        Does early antibiotic use in horses with “strangles” cause metastatic Streptococcus equi bacterial infections?.
        Equine Vet Educ. 2007; 19: 14
        • Fonesca J.D.
        • Mavrides D.E.
        • Morgan A.L.
        • et al.
        Antibiotic resistance in bacteria associated with equine respiratory disease in the United Kingdom.
        Vet Rec. 2020; 187: 189
        • Christmann U.
        • Pink C.
        Lessons learned from a strangles outbreak on a large Standardbred farm.
        Eq Vet Educ. 2017; 29: 138-143
        • Ensink J.M.
        • Bosch G.
        • Van Duijkeren E.
        Clinical efficacy of prophylactic administration of trimethoprim/sulfadiazine in a Streptococcus equi subsp. zooepidemicus infection model in ponies.
        J Vet Pharmacol Ther. 2005; 28: 45
        • Jaramillo-Morales C.
        • Gomez D.E.
        • Renaud D.
        • et al.
        Streptococcus equi culture prevalence, associated risk factors and antimicrobial susceptibility in a horse population from Colombia.
        J Equine Vet Sci. 2022; 111: 103890
        • Plumb D.C.
        Acetylcysteine. In: Plumbs veterinary drug handbook.
        9 th edition. Wiley-Blackwell, Hoboken2018
        • Verheyen K.
        • Newton J.R.
        • Talbot N.C.
        • et al.
        Elimination of guttural pouch infection and inflammation in asymptomatic carriers of Streptococcus equi.
        Equine Vet J. 2000; 32: 527-532
        • Waller A.
        • Robinson C.
        • Newton J.R.
        Further thoughts on the eradication of strangles in equids.
        J Am Vet Med Assoc. 2007; 231: 1335
        • Bowen M.
        Use of a reverse thermodynamic gel to manage chronic shedding in equine strangles.
        Vet Evid. 2017; 2: 109
        • Broux B.
        • Bergen T. van
        • Schauvliege S.
        • et al.
        Successful surgical debridement of a cerebral Streptococcus equi equi abscess by parietal bone flap craniotomy in a 2-month-old Warmblood foal.
        Equine Vet Education. 2019; 31: e58-e62
      1. Strepvax II.
        (Available at:) (Accessed June 29, 2022)
        • Pinnacle I.N.
        (Available at:) (Accessed June 29, 2022)
        • Borst L.B.
        • Patterson S.K.
        • Lanka S.
        • et al.
        Evaluation of a commercially available modified-live Streptococcus equi subsp equi vaccine in ponies.
        Am J Vet Res. 2011; 72: 1130-1138
        • Cursons R.
        • Patty O.
        • Steward K.F.
        • et al.
        Strangles in horses can be caused by vaccination with Pinnacle I.
        N Vaccin. 2015 Jul 9; 33: 3440-3443
        • Robinson C.
        • Frykberg L.
        • Flock M.
        • et al.
        Strangvac: a recombinant fusion protein vaccine that protects against strangles caused by Streptococcus equi.
        Vaccine. 2018; 36: 1484-1490
        • Robinson C.
        • Waller A.S.
        • Frykberg L.
        • et al.
        Intramuscular vaccination with Strangvac is safe and induces protection against equine strangles caused by Streptococcus equi.
        Vaccine. 2020; 38: 4861-4868
        • Ling A.S.
        • Upjohn M.M.
        • Webb K.
        • et al.
        Seroprevalence of Streptococcus equi in working horses in Lesotho.
        Vet Rec. 2011; 169: 72
        • Tirosh-Levy S.
        • Blum S.E.
        • Steward K.F.
        • et al.
        Streptococcus equi subspecies equi in horses in Israel: seroprevalence and strain types.
        Vet Rec Open. 2016; 3: e000187
        • Libardoni F.
        • Machado G.
        • Gressler L.T.
        • et al.
        Prevalence of Streptococcus equi subsp. equi in horses and associated risk factors in the State of Rio Grande do Sul, Brazil.
        Res Vet Sci. 2016; 104: 53-57
        • McGlennon A.
        • Waller A.
        • Verheyen K.
        • et al.
        Surveillance of strangles in UK horses between 2015 and 2019 based on laboratory detection of Streptococcus equi.
        Vet Rec. 2021; 189: e948
        • Jorm L.R.
        Laboratory studies on the survival of Streptococcus equi subspecies equi on surfaces.
        in: Plowright W. Rossdale P.D. Wade J.F. Proceedings of equine infectious diseases VI. R & W Publications Ltd, Newmarket, UK1992: 39-43
        • Weese J.S.
        • Jarlot C.
        • Morley P.S.
        Survival of Streptococcus equi on surfaces in an outdoor environment.
        Can Vet J. 2009; 50: 968-970
        • Durham A.E.
        • Hall Y.S.
        • Kulp L.
        • et al.
        A study of the environmental survival of Streptococcus equi subspecies equi.
        Equine Vet J. 2018; 50: 861-864
        • Pusterla N.
        • Bowers J.
        • Barnum S.
        • et al.
        Molecular detection of Streptococcus equi subspecies equi in face flies (Musca autumnalis) collected during a strangles outbreak on a Thoroughbred farm.
        Med Vet Entomol. 2020; 34: 120-122
        • Svonni E.
        • Andreasson M.
        • Fernström L.L.
        • et al.
        Potential for residual contamination by Streptococcus equi subspp equi of endoscopes and twitches used in diagnosis of carriers of strangles.
        Equine Vet J. 2020; 52: 884-890
        • Torpiano P.
        • Nestorova N.
        • Vella C.
        Streptococcus equi subsp. equi meningitis, septicemia and subdural empyema in a child.
        IDCases. 2020; 21: e00808
        • Willis A.T.
        • Barnum S.
        • Pusterla N.
        Validation of a point-of-care polymerase chain reaction assay for detection of Streptococcus equi subspecies equi in rostral nasal swabs from horses with suspected strangles.
        Can Vet J. 2021; 62: 51-54
        • Boyle A.G.
        • Rankin S.C.
        • O'Shea K.
        • et al.
        Detection of Streptococcus equi subsp. equi in guttural pouch lavage samples using a loop-mediated isothermal nucleic acid amplification microfluidic device.
        J Vet Intern Med. 2021; 35: 1597-1603
        • Pusterla N.
        • Barnum S.M.
        • Byrne B.A.
        Investigation of a 24-Hour Culture Step to Determine the Viability of Streptococcus equi Subspecies equi Via Quantitative Polymerase Chain Reaction in Nasal Secretions From Horses With Suspected Strangles.
        J Equine Vet Sci. 2021; 97: 103328
        • Boyle A.G.
        • O’Shea K.
        • Rankin S.C.
        Propidium Monoazide - Quantitative Realtime Polymerase Chain Reaction for the Detection of Viable Streptococcus equi.
        in: ACVIM forum proceedings. 2018 (Available at:) (Accessed June 29, 2022)
        • Mitchell C.
        • Steward K.F.
        • Charbonneau A.R.L.
        • et al.
        Globetrotting strangles: the unbridled national and international transmission of Streptococcus equi between horses.
        Microb Genom. 2021; 7 (mgen000528)https://doi.org/10.1099/mgen.0.000528