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Review Article| Volume 39, ISSUE 1, P133-145, April 2023

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Equine Granulocytic Anaplasmosis

Published:February 01, 2023DOI:https://doi.org/10.1016/j.cveq.2022.11.011

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      References

        • Barlough J.E.
        • Madigan J.E.
        • DeRock E.
        • et al.
        Protection against Ehrlichia equi is conferred by prior infection with the human granulocytotropic Ehrlichia (HGE agent).
        J Clin Microbiol. 1995; 33: 3333-3334
        • Pusterla N.
        • Anderson R.J.
        • House J.K.
        • et al.
        Susceptibility of cattle to infection with Ehrlichia equi and the agent of human granulocytic ehrlichiosis.
        J Am Vet Med Assoc. 2001; 218: 1160-1162
        • Laus F.
        • Veronesi F.
        • Passamonti F.
        • et al.
        Prevalence of tick borne pathogens in horses from Italy.
        J Vet Med Sci. 2013; 75: 715-720
        • Pusterla N.
        • Chae J.S.
        • Kimsey R.B.
        • et al.
        Transmission of Anaplasma phagocytophila (Human Granulocytic Ehrlichiosis Agent) in Horses Using Experimentally Infected Ticks (Ixodes scapularis).
        J Vet Med Ser B. 2002; 49: 484-488
        • Reubel G.H.
        • Kimsey R.B.
        • Barlough J.E.
        • et al.
        Experimental transmission of Ehrlichia equi to horses through naturally infected ticks (Ixodes pacificus) from Northern California.
        J Clin Microbiol. 1998; 36: 2131-2134
        • Price K.J.
        • Ayres B.N.
        • Maes S.E.
        • et al.
        First detection of human pathogenic variant of Anaplasma phagocytophilum in field-collected Haemaphysalis longicornis, Pennsylvania, USA.
        Zoonoses and Public Health. 2022; 69: 143-148
        • Nieto N.C.
        • Madigan J.E.
        • Foley J.E.
        The dusky-footed woodrat (Neotoma fuscipes) is susceptible to infection by Anaplasma phagocytophilum originating from woodrats, horses, and dogs.
        J Wildl Dis. 2010; 46: 810-817
        • Hauck D.
        • Jordan D.
        • Springer A.
        • et al.
        Transovarial transmission of Borrelia spp., Rickettsia spp. And Anaplasma phagocytophilum in Ixodes ricinus under field conditions extrapolated from DNA detection in questing larvae.
        Parasites and Vectors. 2020; 13: 1-11
        • Ravyn M.D.
        • Kodner C.B.
        • Carter S.E.
        • et al.
        Isolation of the etiologic agent of human granulocytic ehrlichiosis from the white-footed mouse (Peromyscus leucopus).
        J Clin Microbiol. 2001; 39: 335-338
        • Levin M.L.
        • Troughton D.R.
        • Loftis A.D.
        Duration of tick attachment necessary for transmission of Anaplasma phagocytophilum by Ixodes scapularis (Acari: Ixodidae) nymphs.
        Ticks Tick-Borne Dis. 2021; 12: 101819
        • Dixon C.E.
        • Bedenice D.
        Transplacental infection of a foal with Anaplasma phagocytophilum.
        Equine Vet Education. 2021; 33: e62-e66
        • Rikihisa Y.
        Mechanisms of obligatory intracellular infection with Anaplasma phagocytophilum.
        Clin Microbiol Rev. 2011; 24: 469-489
        • Truchan H.K.
        • Cockburn C.L.
        • Hebert K.S.
        • et al.
        The Pathogen-Occupied Vacuoles of Anaplasma phagocytophilum and Anaplasma marginale Interact with the Endoplasmic Reticulum.
        Front Cell Infect Microbiol. 2016; 6: 22
        • Lin M.
        • Rikihisa Y.
        Ehrlichia chaffeensis and Anaplasma phagocytophilum lack genes for lipid A biosynthesis and incorporate cholesterol for their survival.
        Infect Immun. 2003; 71: 5324-5331
        • Herron M.J.
        • Ericson M.E.
        • Kurtti T.J.
        • et al.
        The Interactions of Anaplasma phagocytophilum, Endothelial Cells, and Human Neutrophils.
        Ann N Y Acad Sci. 2005; 1063: 374-382
        • Granquist E.G.
        • Stuen S.
        • Lundgren A.M.
        • et al.
        Outer membrane protein sequence variation in lambs experimentally infected with Anaplasma phagocytophilum.
        Infect Immun. 2008; 76: 120-126
        • Woldehiwet Z.
        Immune evasion and immunosuppression by Anaplasma phagocytophilum, the causative agent of tick-borne fever of ruminants and human granulocytic anaplasmosis.
        Vet J. 2008; 175: 37-44
        • Artursson K.
        • Gunnarsson A.
        • Wikström U.B.
        • et al.
        A serological and clinical follow-up in horses with confirmed equine granulocytic ehrlichiosis.
        Equine Vet J. 1999; 31: 473-477
        • Scharf W.
        • Schauer S.
        • Freyburger F.
        • et al.
        Distinct Host Species Correlate with Anaplasma phagocytophilum ankA Gene Clusters.
        J Clin Microbiol. 2011; 49: 790
      1. Epidemiology and Statistics | Anaplasmosis.
        CDC. 2021; (Available at:)
        • Russell A.
        • Shost N.
        • Burch M.
        • et al.
        Serological and Molecular Detection of Anaplasma spp. in Blood From Healthy Horses: A Preliminary Study of Horses in East Texas.
        J Equine Vet Sci. 2021; 106https://doi.org/10.1016/J.JEVS.2021.103757
        • Medrano-Bugarini R.A.
        • Figueroa-Millán J.V.
        • Rivera-Chavira B.E.
        • et al.
        Detection of Theileria equi, Babesia caballi, and Anaplasma phagocytophilum DNA in Soft Ticks and Horses at Ciudad Juarez, Mexico.
        . 2019; 44: 647-658
        • Schvartz G.
        • Epp T.
        • Burgess H.J.
        • et al.
        Seroprevalence of equine granulocytic anaplasmosis and lyme borreliosis in Canada as determined by a point-of-care enzyme-linked immunosorbent assay (ELISA).
        Can Vet J. 2015; 56: 575
        • dos Santos T.M.
        • Roier E.C.R.
        • Pires M.S.
        • et al.
        Molecular evidence of Anaplasma phagocytophilum and Theileria equi coinfection in horses from Rio de Janeiro, Brazil.
        Vet Anim Sci. 2019; 7: 100055
        • Hurtado C.
        • Torres R.
        • Pérez-Macchi S.
        • et al.
        Serological and molecular detection of Anaplasma phagocytophilum in Thoroughbred horses from Chilean racecourses.
        Ticks Tick-Borne Dis. 2020; 11https://doi.org/10.1016/J.TTBDIS.2020.101441
        • Slivinska K.
        • Víchová B.
        • Werszko J.
        • et al.
        Molecular surveillance of Theileria equi and Anaplasma phagocytophilum infections in horses from Ukraine, Poland and Slovakia.
        Vet Parasitol. 2016; 215: 35-37
        • Dziegiel B.
        • Adaszek L.
        • Winiarczyk M.
        • et al.
        Comparative analysis of 16S RNA nucleotide sequences of Anaplasma phagocytophilum detected in the blood of horses from various parts of Europe.
        J Med Microbiol. 2013; 62: 1891-1896
        • Bogdan A.M.
        • Ionita M.
        • Mitrea I.L.
        Serological Evidence of Natural Exposure to Tick-Borne Pathogens in Horses, Romania.
        Microorganisms. 2021; 9: 373
        • Günaydin E.
        • Pekkaya S.
        • Kuzugüden F.
        • et al.
        The first detection of anti-anaplasma phagocytophilum antibodies in horses in Turkey.
        Kafkas Universitesi Veteriner Fakultesi Dergisi. 2018; 24: 867-871
        • Villa L.
        • Gazzonis A.L.
        • Allievi C.
        • et al.
        Seroprevalence of Tick-Borne Infections in Horses from Northern Italy.
        Animals (Basel). 2022; 12: 999
        • Giudice E.
        • Giannetto C.
        • Furco V.
        • et al.
        Anaplasma phagocytophilum seroprevalence in equids: a survey in Sicily (Italy).
        Parasitol Res. 2012; 111: 951-955
        • Passamonti F.
        • Veronesi F.
        • Cappelli K.
        • et al.
        Anaplasma phagocytophilum in horses and ticks: a preliminary survey of Central Italy.
        Comp Immunol Microbiol Infect Dis. 2010; 33: 73-83
        • von Loewenich F.D.
        • Stumpf G.
        • Baumgarten B.U.
        • et al.
        A case of equine granulocytic ehrlichiosis provides molecular evidence for the presence of pathogenic anaplasma phagocytophilum (HGE agent) in Germany.
        Eur J Clin Microbiol Infect Dis. 2003; 22: 303-305
        • Walls J.J.
        • Greig B.
        • Neitzel D.F.
        • et al.
        Natural infection of small mammal species in Minnesota with the agent of human granulocytic ehrlichiosis.
        J Clin Microbiol. 1997; 35: 853-855
        • Butler C.M.
        • Nijhof A.M.
        • Jongejan F.
        • et al.
        Anaplasma phagocytophilum infection in horses in the Netherlands.
        Vet Rec. 2008; 162: 216-218
        • Tsachev I.
        • Pantchev N.
        • Marutsov P.
        • et al.
        Serological Evidence of Borrelia burgdorferi, Anaplasma phagocytophilum and Ehrlichia Spp. Infections in Horses from Southeastern Bulgaria.
        Vector Borne Zoonotic Dis (Larchmont, N.Y.). 2018; 18: 588-594
        • Hansen M.G.B.
        • Christoffersen M.
        • Thuesen L.R.
        • et al.
        Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in Danish horses.
        Acta Vet Scand. 2010; 52https://doi.org/10.1186/1751-0147-52-3
        • Janzén T.
        • Petersson M.
        • Hammer M.
        • et al.
        Equine Granulocytic Anaplasmosis in Southern Sweden: Associations with coniferous forest, water bodies and landscape heterogeneity.
        Agric Ecosyst Environ. 2019; 285: 106626
        • Jahn P.
        • Zeman P.
        • Bezdekova B.
        • et al.
        Equine granulocytic anaplasmosis in the Czech Republic.
        Vet Rec. 2010; 166: 646-649
        • Maurizi L.
        • Marié J.L.
        • Courtin C.
        • et al.
        Seroprevalence survey of equine anaplasmosis in France and in sub-Saharan Africa.
        Clin Microbiol Infect. 2009; 15: 68-69
        • Albadrani B.A.
        • Al-Iraqi O.M.
        First detection of equine anaplasmosis and hemoplasmosis of horses in Mosul City, Iraq.
        Adv Anim Vet Sci. 2019; 7: 106-111
        • Saleem S.
        • Ijaz M.
        • Farooqi S.H.
        • et al.
        First molecular evidence of equine granulocytic anaplasmosis in Pakistan.
        Acta Trop. 2018; 180: 18-25
        • ben Said M.
        • Belkahia H.
        • Mejed Héni M.
        • et al.
        Seroprevalence of Anaplasma phagocytophilum in well-maintained horses from northern Tunisia.
        Trop Biomed. 2014; 31: 432-440
        • Mghirbi Y.
        • Yach H.
        • Ghorbel A.
        • et al.
        Anaplasma phagocytophilum in horses and ticks in Tunisia.
        Parasites and Vectors. 2012; 5: 1-7
        • Madigan J.E.
        • Gribble D.
        Equine ehrlichiosis in northern California: 49 cases (1968-1981).
        J Am Vet Med Assoc. 1987; 190 (Available at:): 445-448
        • Lewis S.R.
        • Zimmerman K.
        • Dascanio J.J.
        • et al.
        Equine Granulocytic Anaplasmosis: A Case Report and Review.
        J Equine Vet Sci. 2009; 29: 160-166
        • Siska W.D.
        • Tuttle R.E.
        • Messick J.B.
        • et al.
        Clinicopathologic Characterization of Six Cases of Equine Granulocytic Anaplasmosis In a Nonendemic Area (2008-2011).
        J Equine Vet Sci. 2013; 33: 653-657
        • Franzén P.
        • Aspan A.
        • Egenvall A.
        • et al.
        Acute Clinical, Hematologic, Serologic, and Polymerase Chain Reaction Findings in Horses Experimentally Infected with a European Strain of Anaplasma phagocytophilum.
        J Vet Intern Med. 2005; 19: 232-239
        • Gussmann K.
        • Czech C.
        • Hermann M.
        • et al.
        Anaplasma phagocytophilum infection in a horse from Switzerland with severe neurological symptoms.
        Schweizer Archiv Fur Tierheilkunde. 2014; 156: 345-348
        • Nolen-Walston R.D.
        • D’oench S.M.
        • Hanelt L.M.
        • et al.
        Acute recumbency associated with Anaplasma phagocytophilum infection in a horse.
        J Am Vet Med Assoc. 2004; 224: 1964-1966
        • Nowicka B.
        • Polkowska I.
        • Adaszek L.
        • et al.
        Horse anaplasmosis as a cause of CNS infections and the use of computed tomography as a diagnostic imaging tool to present of its cerebral form: literature review supplemented with a clinical case.
        Med Weter. 2022; 78: 239-243
        • Deane E.L.
        • Fielding C.L.
        • Rhodes D.M.
        • et al.
        Upper respiratory signs associated with Anaplasma phagocytophilum infection in two horses.
        Equine Vet Education. 2021; 33: e58-e61
        • Restifo M.M.
        • Bedenice D.
        • Thane K.E.
        • et al.
        Cavitary Effusion Associated with Anaplasma phagocytophilum Infection in 2 Equids.
        J Vet Intern Med. 2015; 29: 732
        • Hilton H.
        • Madigan I.E.
        • Aleman M.
        Rhabdomyolysis Associated with Anaplasma phagocytophilum Infection in a Horse.
        J Vet Intern Med. 2008; 22: 1061-1064
        • Franzén P.
        • Berg A.L.
        • Aspan A.
        • et al.
        Death of a horse infected experimentally with Anaplasma phagocytophilum.
        Vet Rec. 2007; 160: 122-125
        • Madigan J.E.
        • Hietala S.
        • Chalmers S.
        • et al.
        Seroepidemiologic survey of antibodies to Ehrlichia equi in horses of northern California.
        J Am Vet Med Assoc. 1990; 196 (Available at:): 1962-1964
        • van Andel A.E.
        • Magnarelli L.A.
        • Heimer R.
        • et al.
        Development and duration of antibody response against Ehrlichia equi in horses.
        J Am Vet Med Assoc. 1998; 212 (Available at:): 1910-1914
        • Johnson A.L.
        • Divers T.J.
        • Chang Y.F.
        Validation of an in-clinic enzyme-linked immunosorbent assay kit for diagnosis of Borrelia burgdorferi infection in horses.
        J Vet Diagn Invest. 2008; 20: 321-324
        • Franzén P.
        • Aspan A.
        • Egenvall A.
        • et al.
        Molecular evidence for persistence of Anaplasma phagocytophilum in the absence of clinical abnormalities in horses after recovery from acute experimental infection.
        J Vet Intern Med. 2009; 23: 636-642
        • Maurin M.
        • Bakken J.S.
        • Dumler J.S.
        Antibiotic Susceptibilities of Anaplasma (Ehrlichia) phagocytophilum Strains from Various Geographic Areas in the United States.
        Antimicrob Agents Chemother. 2003; 47: 413
        • Buitrago M.I.
        • Ijdo J.W.
        • Rinaudo P.
        • et al.
        Human granulocytic ehrlichiosis during pregnancy treated successfully with rifampin.
        Clin Infect Dis. 1998; 27: 213-215
        • Davies R.S.
        • Madigan J.E.
        • Hodzic E.
        • et al.
        Dexamethasone-Induced Cytokine Changes Associated with Diminished Disease Severity in Horses Infected with Anaplasma phagocytophilum.
        Clin Vaccin Immunol : CVI. 2011; 18: 1962
        • Fischhoff I.R.
        • Keesing F.
        • Pendleton J.
        • et al.
        Assessing Effectiveness of Recommended Residential Yard Management Measures Against Ticks.
        J Med Entomol. 2019; 56: 1420
        • Prose R.
        • Breuner N.E.
        • Johnson T.L.
        • et al.
        Contact Irritancy and Toxicity of Permethrin-Treated Clothing for Ixodes scapularis, Amblyomma americanum, and Dermacentor variabilis Ticks (Acari: Ixodidae).
        J Med Entomol. 2018; 55: 1217-1224
        • Stuen S.
        • Granquist E.
        • Silaghi C.
        Anaplasma phagocytophilum - pathogen with a zoonotic potential.
        Parasites & Vectors. 2014; 7: O24